The standard Clophosome® (neutral and the anionic at 7mg/mL clodronate disodium concentration) are our most popular clodronate liposome products for in vivo macrophage depletion. Clodronate molecules are encapsulated in medium-sized (500-2000nm) MLV liposomes for superior activity, physical and chemical stability, and convenience of use and handling. The neutral Clophosome® is capable of achieving macrophage depletion of 80-90% in spleen after a single intravenous or intraperitoneal administration. Clophosome® - A, a second generation Clodronate liposomes, composed of anionic lipids further improve the efficacy in macrophage depletion to above 90% in spleen after a single intravenous injection. The anionic Clophosome® - A is also very effective for in vitro macrophage depletion.
For your convenience, the Clophosome® products are provided in various combo kits and vial sizes (2mL and 10mL). Evaluation samples are also available upon request. See below for results and product details.
|
Product Code |
Description |
Price (2mL) |
Price (10mL) |
|
Free sample kit 1 vial (1mL) Clophosome® (neutral) 1 vial (1mL) Clophosome®-A (anionic) |
Shipping/handling $60-USA $80 Canada $100- international |
n/a |
|
|
Clophosome® -Clodronate liposomes (neutral) |
$169 |
$618 |
|
|
Clophosome®-A-Clodronate liposomes (anionic) |
$261 |
$923 |
|
|
Plain control liposomes (neutral) |
$94 |
$314 |
|
|
Plain Control liposomes (anionic) |
$136 |
$461 |
|
|
DiI Fluorescent control liposomes (neutral) |
$189 |
n/a |
|
|
DiI fluorescent control liposomes (anionic) |
$219 |
n/a |
|
|
Combo: 1 vial Clophosome® (neutral) 1 vial control neutral liposomes |
$209 |
$734 |
|
|
Combo: 1 vial Clophosome®-A (anionic) 1 vial control anionic liposomes |
$314 |
$1070 |
|
Product Code |
Description |
Ex/Em (nm) |
Thermofisher Cat# |
|
Fluorescent DiO control liposomes for Clophosome® (neutral) |
484/501 |
D275 |
|
|
Fluorescent DiO control liposomes for Clophosome®-A (anionic) |
484/501 |
D275 |
|
|
DiI Fluorescent control liposomes for Clophosome® (neutral) |
549/565 |
D282 |
|
|
DiI Fluorescent control liposomes for Clophosome®-A (anionic) |
549/565 |
D282 |
|
|
Fluorescent DiA control liposomes for Clophosome® (neutral) |
456/590 |
D3883 |
|
|
Fluorescent DiA control liposomes for Clophosome®-A (anionic) |
456/590 |
D3883 |
|
|
Fluorescent DiD control liposomes for Clophosome® (neutral) |
644/665 |
D307 |
|
|
Fluorescent DiD control liposomes for Clophosome®-A (anionic) |
644/665 |
D307 |
|
|
Fluorescent DiR control liposomes for Clophosome® (neutral) |
750/780 |
D12731 |
|
|
Fluorescent DiR control liposomes for Clophosome®-A (anionic) |
750/780 |
D12731 |
Product Sheet for Clophosome®- A
Product sheet for lyophilized Clophosome®
Product sheet for lyophilized Clophosome®- A
Publications on Clophosome® (neutral)
Publications on Clophosome® - A (anionic)
Caution: CLEAN with Alcohol and DO NOT Reuse the Needles
It is very important to follow the instruction, particularly for long-term macrophage depletion (more than a week). Animals become sensitive to infection when macrophages are depleted, and their immune system is compromised. Animal sickness and even death may result if they are handled improperly. It is extremely important to conduct the injection in a clean environment. Withdraw the liposomes through the rubber stopper (clean with alcohol first) with a new sterile needle. Always clean the injection site with alcohol and use a new and sterile needle for each injection. Keep the animal cages clean. Open the vials in a biological safety cabinet (BSC hood) and DO NOT contaminate the Clophosome® reagent.
A good practice is to include a few extra animals for long-term experiments, as occasional animal death may occur. Test with a small group of animals first if you are a new user or using a new administration regimen. Treated properly these animals (mice) could survive for over a month even with twice-a-week injection of our clodronate liposomes.
