NOTICE: All contract research and drug delivery formulation services are provided for preclinical and in-vitro laboratory research purposes only. FormuMax Scientific does not provide services for human diagnostic, therapeutic, or clinical use.
FormuMax Scientific provides specialized contract drug delivery formulation development for the pharmaceutical and biotechnology industries. We offer expert-level biochemical engineering solutions for complex delivery challenges, specifically focusing on high-molecular weight protein-liposome conjugation (150 kDa to 500 kDa trimers) and advanced mRNA/nucleic acid encapsulation.
Our technical team leverages decades of experience in lipid biophysics to assist clients with formulation feasibility, process scale-up (from milliliters to tens of liters), and rigorous analytical characterization.
Formulation Development Capabilities
- Advanced Lipid Nanoparticles (LNPs) and specialty lipid-based systems
- Complex protein-liposome conjugation (Maleimide-Thiol and Click Chemistry)
- Formulation of small molecules, peptides, and nucleic acids
- Solubility enhancement and controlled/slow drug release systems
- Process development using microfluidization, extrusion, and homogenization
- Design-of-Experiments (DoE) for process optimization and sterile filterability
Technical Characterization & Instrumentation
- Particle size & distribution (Brookhaven 90Plus, ZetaPALS, and qNano)
- Zeta Potential and Mobility measurements
- Drug encapsulation efficiency and morphology (cryo-TEM, FF-EM)
- Phase transition and protein denaturation studies (MicroCal VP-DSC)
- Lyophilization development (Virtis Genesis 35EL with stoppering)
Analytical Sciences
- HPLC method development for drug potency and degradation
- Lipid concentration assays and formulation stability testing
- In vitro drug release assays and osmolality (Wescor 5520)