We specialize in a range of formulation and drug delivery technologies from solubility enhancement using liposomes, lipospheres and micellar systems to more sophisticated nano-enabled systems like PEGylated liposomes, PEGylated lipospheres and polymer-based nanoparticles for controlled/sustained delivery of various type of compounds. We have strong expertise and many years of experience in designing and developing parenteral delivery systems with respect to both the drug carrier systems and the drug loading methods for challenging compounds. Our goal is to come up with formulation solutions that are tailored and optimized to fit the compound and the specific needs of our customers.
Our Expertise:
- Development of new carriers and drug loading technologies
- Conventional liposomes
- Long-circulating PEGylated liposomes
- Lipid-based nanoparticles or lipid-particles
- Microemulsions
- Controlled release and/or solubility enhancement
- Optimization of formulation parameters using DOE (Design of Experiments)
- Liposomes for pharmaceuticals (small molecules, nucleic acids, peptide/proteins)
- Liposomes for cosmetics (topical)
- Liposomes for nutraceuticals
Benefits with Our Technology:
- Accumulation enhancement at the disease site through prolonged circulation
- Improve PK/PD relationship
- Increase in therapeutic efficacy
- Enhancement of skin penetration
- Enhancement of GI absorption
- Reduction of dosing frequency
- Solubilization of water-insoluble compounds
- Reduction in toxicity
- Stability enhancement
Evolution of Liposome
First generation: Conventional Liposomes
This is the first generation liposome system. Various types of drugs can be loaded into the interior,
in the bilayer or at the interface depending on the nature of the compounds.
Second generation: PEGylated STEALTH Liposomes
PEGylated (STEALTH) liposomes is the second generation liposome system. It offers significant
advantages over conventional liposomes. It has prolonged blood circulation time and hence enhanced
drug accumulation at the disease site. Other potential benefits include reduced toxicity, reduced dosing
frequency etc.
Third generation: Ligand-Targeted STEALTH Liposomes
This is the most advanced liposome system. PEGylated liposomes with targeting ligands
(antibodies, antibody fragments, peptides and small molecules) have the potential of specific
targeted delivery to the disease site through ligand-receptor binding.
STEALTH Lipid-Nanoparticles (Lipospheres)
Liposphere is a nano-particle with an lipophilic core (such as triglycerides) coated with a monolayer of lipids.
Lipophilic drugs are loaded in the oil core.