Cationic liposomes are one of the most versatile system in gene therapy, mRNA/siRNA therapeutics as well as vaccine adjuvants. Cationic liposomes form stable complexes (Lipoplex) with DNA, RNA, oligos and proteins. FormuMax provides a number of popular cationic liposome reagents made form popular cationic lipids, such as DOTAP, DMTAP, DDAB, DC-CHOL. These cationic liposomes are prepared in nuclease-free water under sterile/low endotoxin conditions to the highest quality. Small LUV particle sizes are achieved that is the most suitable for forming small and stable lipoplexes with your nucleic acids. We also offer services for custom-making of cationic liposomes using the lipids of your choice.
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Popular cationic lipids and helper lipids
DOTAP (18:1 TAP, CAS 132172-61-3) 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)
DC-CHOL (CAS 166023-21-8) 3b-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride
DOTMA (CAS 104872-42-6) 1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)
DDAB (18:0 DDAB) (CAS 3700-67-2) Dimethyldioctadecylammonium (Bromide Salt)
Common helper lipids
DOPE (18:1 (Δ9-Cis) PE, CAS 4004-05-1) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
CHOL (cholesterol, CAS 57-88-5)