Cationic Liposomes

Cationic liposomes are one of the most versatile system in gene therapy, mRNA/siRNA therapeutics as well as vaccine adjuvants. Cationic liposomes form stable complexes (Lipoplex) with DNA, RNA, oligos and proteins. FormuMax provides a number of popular cationic liposome reagents made form popular cationic lipids, such as DOTAP, DMTAP, DDAB, DC-CHOL. These cationic liposomes are prepared in nuclease-free water under sterile/low endotoxin conditions to the highest quality. Small LUV particle sizes are achieved that is the most suitable for forming small and stable lipoplexes with your nucleic acids. We also offer services for custom-making of cationic liposomes using the lipids of your choice. 

Please contact us for inquiries. 

 

Popular cationic lipids and helper lipids

DOTAP (18:1 TAP, CAS 132172-61-31,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

18:1 TAP (DOTAP)

 

 DC-CHOL (CAS 166023-21-8) 3b-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride

   DC-Cholesterol∙HCl

 

DOTMA (CAS 104872-42-6) 1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)

 

 DOTMA

 

DDAB (18:0 DDAB) (CAS 3700-67-2) Dimethyldioctadecylammonium (Bromide Salt)

 

18:0 DDAB

 

Common helper lipids

 

DOPE (18:1 (Δ9-Cis) PE, CAS 4004-05-1) 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine

18:1 (Δ9-Cis) PE (DOPE)

 

CHOL (cholesterol, CAS 57-88-5) 

cholesterol (ovine)