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Clophosome® - Clodronate Liposomes

 

New products: Lyophilized Clophosome® (1 year shelf-life)

Neutral Clophosome® (F70101C-NL)         Anionic Clophosome® - A (F70101C-AL)

FormuMax proudly offers two products of clodronate liposomes. Clophosome® with the clodronate molecules encapsulated in neutral liposomes is capable of achieving macrophage depletion of 80-90% in spleen after a single intravenous or intraperitoneal administration. Clophosome®-A composed of anionic lipids further improve the efficacy in macrophage depletion to above 90% in spleen after a single intravenous injection. Clodronate molecules are encapsulated in small MLV liposomes for superior activity, physical and chemical stability, and convenience of use and handling . 

For your convenience, the products are provided in various combo kits and vial sizes (2mL and 10mL). Evaluation samples are also available upon request. See below for results and product details.

We have recently added two new forms of Clophosome® products. The first being the high potency neutral Clophosome® (20mg/mL) so that high amount of Clophosome® could be dosed when the dosing volume is small, such as intratracheal, intranasal,  Intracerebroventricular (ICV) or intratumor injections. 

We have also introduced lyophilized Clophosome® (both neutral and anionic forms) which give exceptional shelf-life of one year. The Clophosome® can be easily reconstituted to regenerate Clophosome® comparable to the original liquid Clophosome®. 

 

clophosome-flow-cyto-i.v..jpg                         

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.v. injection of liposomes (results used with permission)

 

clophosome-flow-cyto-i.p..jpg

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.p. injection of liposomes (results used with permission)

 (Note: the above results are illustrations only, your results may vary depending on individual applications, types of animals and administration regimens and many other factors) 

Clophosome Product Brochure

Lyophilized Clophosome® Brochure

Product sheet for Clophosome®

Product Sheet for Clophosome®- A

Product sheet for lyophilized Clophosome®

Product sheet for lyophilized Clophosome®- A

MSDS

 

New products: Lyophilized Clophosome®

Product Code

  Description

        Price (5 mL)

         F70101C-NL

      Clophosome® - Lyophilized Clodronate Liposomes (Neutral)

            $349

         F70101C-AL

      Clophosome®-A - Lyophilized Clodronate Liposomes (Anionic)

            $529

       F70101-NL (New)

      Control for lyophilized Clophosome® (Neutral)

            $169

         F70101-AL (New)

      Control for lyophilized Clophosome® - A (Anionic)

            $259

 

New products: High Potency Clophosome® 

Product Code

Description 

        Price (1 mL)

  F70101C-NH (New) 

     Clophosome® - high potency clodronate liposomes (neutral, 20mg/mL)

               $399

F70101-NH (New)

     Control empty liposomes for Clophosome® ,high potency (neutral)                $149

F70101C-AH (New)

     Clophosome® -A- high potency clodronate liposomes (anionic, 20mg/mL)                $499
              F70101-AH (new)      Control empty liposomes for Clophosome® - A, high potency (anionic)                $219

 

Product Code

   Description

Price (2mL)

Price (10mL)

F70101C-NAS

              Free sample kit 

       1 vial (1mL) Clophosome®  (neutral) 

                1 vial (1mL) Clophosome®-A (anionic)

Shipping/handling

$50-USA

$80 Canada

$100- international

  n/a

F70101C-N

           Clophosome®  - Clodronate   Liposomes (neutral)

$199

$699

F70101C-A

  Clophosome®-A - Clodronate   Liposomes (anionic)

$299

$1049

F70101-N

  Plain control Liposomes (Neutral)

$99

$349

F70101-A

  Plain Control Liposomes (Anionic)

 $149

 $519

F70101F-N

  DiI Fluorescent Control Liposomes (Neutral)

 $149

 $519

F70101F-A

  DiI Fluorescent Control Liposomes (Anionic)

 $199

 $699

F70101C-NC

  Combo:   1 vial Clophosome®  (neutral)

                          1 vial control neutral liposomes

$239

$839

F70101C-AC

  Combo:   1 vial Clophosome®-A

                1 vial control anionic liposomes

$349

$1219

 

Fluorescent Control Liposomes for Clophosome 

Product Code  Description Ex/Em (nm) Invitrogen Cat#
F70101FO-N Fluorescent DiO Control Liposomes for Clophosome® (Neutral) 484/501 D275
F70101FO-A Fluorescent DiO Control Liposomes for Clophosome®-A (Anionic) 484/501 D275
F70101F-N DiI Fluorescent Control Liposomes for Clophosome® (Neutral) 549/565 D282
F70101F-A DiI Fluorescent Control Liposomes for Clophosome®-A (Anionic) 549/565 D282
F70101FA-N Fluorescent DiA Control Liposomes for Clophosome® (Neutral) 456/590 D3883
F70101FA-A Fluorescent DiA Control Liposomes for Clophosome®-A (Anionic) 456/590 D3883
F70101FD-N Fluorescent DiD Control Liposomes for Clophosome® (Neutral) 644/665 D307
F70101FD-A Fluorescent DiD Control Liposomes for Clophosome®-A (Anionic) 644/665 D307
F70101FR-N Fluorescent DiR Control Liposomes for Clophosome® (Neutral) 750/780 D12731
F70101FR-A Fluorescent DiR Control Liposomes for Clophosome®-A (Anionic) 750/780 D12731

 

IMPORTANT NOTES FOR USING CLOPHOSOMES

CLEAN with alcohol and DO NOT reuse the needles

It is very important to follow this instruction, particularly for long-term macrophage depletion (more than a week). Animals become sensitive to infection when macrophages are depleted and their immune system is compromised. Animal sickness and even death may result if they are handled improperly. It is extremely important to conduct the injection in a clean environment. Withdraw the liposomes through the rubber stopper (clean with alcohol first) with a new sterile needle. Always clean the injection site with alcohol and use a new and sterile needle for each injection. Keep the animal cages clean.  Open the vials in a biological safety cabinet (BSC hood) and DO NOT contaminate the Clophosomes.

A good practice is to include a few extra animals for long-term experiments, as occasional animal death may occur. Test with a small group of animals first if you are a new user or using a new administration regimen. Treated properly these animals (mice) could survive for over a month even with twice-a-week injection of our clodronate liposomes.

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  • Clophosome(TM)  (2 mL and 10mL vials)
    $199.00 Clophosome® - Clodronate Liposomes (Neutral)
    Clophosome®- Clodronate Liposomes (Neutral) Clophosome®, neutral clodronate liposomes, offers highly efficient in vivo macrophage depletion. Clodronate molecules are encapsulated in small MLV liposomes for...

  • Clophosome(TM)  (2 mL and 10mL vials)
    $399.00 Clophosome® - High Potency Clodronate Liposomes (Neutral, 20mg/mL)
    High Potency Clophosome®- Clodronate Liposomes (Neutral, 1.0 mL, 20 mg/mL) High potency Clophosome® is created to satisfy the demand for small volume dosing of concentrated clodronate liposomes through routes that...

  • Clophosome-A™- Clodronate Liposomes (anionic) available from FormuMax
    $299.00 Clophosome®-A - Clodronate Liposomes (Anionic)
    Clophosome®-A- Clodronate Liposomes (Anionic) Clophosome®-A, negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes...

  • Clophosome®-A, Fluorescent & Plain Control Liposomes
    $519.00 Clophosome®-A, Fluorescent & Plain Control Liposomes
    Combo: Clophosome® - A, the Fluorescent liposomes and the Control Liposomes Product code: F70101C-AF  This kit consists of the following items 1 vial (2 or 10mL) of Clophosome® - clodronate...

  • Combo Kit:  Clophosome®, Clophosome®- A And Control Liposomes
    $599.00 Combo Kit: Clophosome®, Clophosome®- A And Control Liposomes
    Combo:  Clophosome® and Clophosome®-A And Control Liposomes This all-in-one set is an excellent choice if you want to evaluate and compare the two clodronate liposome products. Included in this kit are one...

  • Clophosome™- Clodronate Liposomes (Neutral) and its control liposomes from FormuMax
    $239.00 Combo: Clophosome® and Control Liposomes
    Clophosome® and Control Liposomes Combo Included in this convenience combo kit are 1 vial of the neutral clodronate liposomes and 1 vial of control liposomes. You save 20%.   Product code:...

  • Combo: Clophosome®, Fluorescent & Plain Control Liposomes (Neutral)
    $359.00 Combo: Clophosome®, Fluorescent & Plain Control Liposomes (Neutral)
    Combo: Clophosome® and the Fluorescent and Control Liposomes Product code: F70101C-NC  This kit consists of the following items 1 vial (2 or 10mL) of Clophosome® - clodronate liposomes (F70101C-N) 1...

  • Combo: Clophosome®-A and Control Liposomes (anionic)
    $349.00 Combo: Clophosome®-A and Control Liposomes (anionic)
    Combo: Clophosome®-A and Control Liposomes  Included in this convenience combo kit are 1 vial of the anionic clodronate liposomes and 1 vial of the anionic control liposomes. Your save is more than 20%...

  • Control liposomes for Clophosome (right)
    $149.00 Control Liposomes for High Potency Clophosome® (Neutral, 1.0mL)
    Empty Control Liposomes for high potency Clophosome® (Neutral, 1.0mL) This product of empty liposomes are made to match the physical and chemical attributes of the high potency neutral Clophosome® without the...

  • Control liposomes for Clophosome (right)
    $219.00 Control Liposomes for High Potency Clophosome® - A (Anionic)
    Empty Control Liposomes for high potency Clophosome® (Anionic, 1.0 mL) This product of empty liposomes are made to match the physical and chemical attributes of the high potency anionic Clophosome® without the...

  • Control liposomes for Clophosome (right)
    $259.00 Control Liposomes for Lyophilized Clophosome® -A (Anionic, 5mL)
    Lyophilized Empty Control Liposomes for Clophosome® - A (anionic, 5.0mL) This product of empty liposomes are made to match the physical and chemical attributes of the lyophilized Clophosome® without the active...

  • Control liposomes for Clophosome (right)
    $169.00 Control Liposomes for Lyophilized Clophosome® (Neutral, 5mL)
    Lyophilized Empty Control Liposomes for Clophosome® (Neutral, 5.0mL) This product of empty liposomes are made to match the physical and chemical attributes of the lyophilized Clophosome® without the active...

  • DiI Fluorescent Control Liposomes (Neutral)
    $149.00 DiI Fluorescent Control Liposomes (Neutral)
    DiI-Labeled Fluorescent Control Liposomes for Clophosome® (Neutral) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and chemical...

  • DiI Fluorescent Control Liposomes for Clophosome®-A (Anionic)
    $199.00 DiI Fluorescent Control Liposomes for Clophosome®-A (Anionic)
    DiI-Labeled Fluorescent Control Liposomes for Clophosome®-A (Anionic) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and...

  • Evaluation Samples:  Clophosome®
    Evaluation Samples: Clophosome®
    Evaluation sample : Clophosome® It is a good idea to get to know our products and test out if they work for your particular application. Included in this evaluation sample kit are 1 vial of the Clophosome® and 1...

  • Fluorescent DiA Control Liposomes for Clophosome (Neutral)
    $179.00 Fluorescent DiA Control Liposomes for Clophosome (Neutral)
    DiA Labeled Fluorescent Control Liposomes for Clophosome® (Neutral) The fluorescent control liposomes contain the lipophilic dye DiA incorporated in the bilayers. It has comparable physical and chemical...


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