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Clophosome® - Clodronate Liposomes

New products: Lyophilized Clophosome® (1 year shelf-life)

Neutral form (F70101C-NL)         Anionic form (F70101C-AL)

FormuMax proudly offers two products of clodronate liposomes. Clophosome® with the clodronate molecules encapsulated in neutral liposomes is capable of achieving macrophage depletion of 80-90% in spleen after a single intravenous or intraperitoneal administration. Clophosome®-A composed of anionic lipids further improve the efficacy in macrophage depletion to above 90% in spleen after a single intravenous injection. Clodronate molecules are encapsulated in small MLV liposomes for superior activity, physical and chemical stability, and convenience of use and handling . 

For your convenience, the products are provided in various combo kits and vial sizes (2mL and 10mL). Evaluation samples are also available upon request. See below for results and product details.

We have recently added two new forms of Clophosome® products. The first being the high potency neutral Clophosome® (20mg/mL) so that high amount of Clophosome® cold be dosed when the dosing volume is small, such as intratracheal, intranasal,  Intracerebroventricular (ICV) or intratumor injections. 

We have also introduced lyophilized Clophosome® (both neutral and anionic forms) which give exceptional shelf-life of one year. The Clophosome® can be easily reconstituted to regenerate the same Clophosome® as the original liquid Clophosome®. 

 

clophosome-flow-cyto-i.v..jpg                         

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.v. injection of liposomes (results used with permission)

 

clophosome-flow-cyto-i.p..jpg

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.p. injection of liposomes (results used with permission)

 (Note: the above results are illustrations only, your results may vary depending on individual applications, types of animals and administration regimens and many other factors) 

Clophosome Product Brochure

Product sheet for Clophosome®

Product Sheet for Clophosome®- A

MSDS

 

New product: Lyophilized Clophosome®

Product Code

  Description

 

     Price (5 mL)

F70101C-NL (New)

      Clophosome® - Lyophilized Clodronate Liposomes (Neutral)

 

            $399

F70101C-AL (New)

      Clophosome®-A - Lyophilized Clodronate Liposomes (Anionic)

 

            $549

 

High Potency Clophosome®  F70101C-NH

Product Code

  Description

 

      Price (1 mL)

F70101C-NH (New)

      Clophosome® - high potency clodronate  Liposomes

                 (Neutral, 20mg/mL)

 

            $499

 

Product Code

  Description

 

Price (2mL)

 

Price (10mL)

F70101C-NAS

              Free sample kit 

       1 vial (1mL) Clophosome®  (neutral) 

                1 vial (1mL) Clophosome®-A (anionic)

 

Shipping/handling

$50-USA

$80 Canada

$100- international

 

  n/a

F70101C-N

           Clophosome®  - Clodronate   Liposomes (neutral)

 

$199

 

$699

F70101C-A

  Clophosome®-A - Clodronate   Liposomes (anionic)

 

$299

 

$1049

F70101-N

  Plain control Liposomes (Neutral)

 

$99

 

$349

F70101-A

  Plain Control Liposomes (Anionic)

 

 $149

 

 $519

F70101F-N

  DiI Fluorescent Control Liposomes (Neutral)

 

 $149

 

 $519

F70101F-A

  DiI Fluorescent Control Liposomes (Anionic)

 

 $199

 

 $699

F70101C-NC

  Combo:   1 vial Clophosome®  (neutral)

                             1 vial control neutral liposomes

 

$239

 

$839

F70101C-AC

  Combo:   1 vial Clophosome®-A

                  1 vial control anionic liposomes

 

$349

 

$1219

F70101C-NF

  Combo:    1 vial Clophosome®  (neutral)

   1 vial Plain control liposomes (neutral)

              1 vial  DiI Fluorescent control liposomes (neutral)

 

$359

 

$1439

F70101C-AF

  Combo:    1 vial Clophosome®-A (anionic)

   1 vial Plain control liposomes (anionic)

                   1 vial  DiI Fluorescent control liposomes (anionic)

 

$519

 

$2019

 

Fluorescent Control Liposomes for Clophosome 

Product Code  Description Ex/Em (nm) Invitrogen Cat#
F70101FO-N Fluorescent DiO Control Liposomes for Clophosome® (Neutral) 484/501 D275
F70101FO-A Fluorescent DiO Control Liposomes for Clophosome®-A (Anionic) 484/501 D275
F70101F-N DiI Fluorescent Control Liposomes for Clophosome® (Neutral) 549/565 D282
F70101F-A DiI Fluorescent Control Liposomes for Clophosome®-A (Anionic) 549/565 D282
F70101FA-N Fluorescent DiA Control Liposomes for Clophosome® (Neutral) 456/590 D3883
F70101FA-A Fluorescent DiA Control Liposomes for Clophosome®-A (Anionic) 456/590 D3883
F70101FD-N Fluorescent DiD Control Liposomes for Clophosome® (Neutral) 644/665 D307
F70101FD-A Fluorescent DiD Control Liposomes for Clophosome®-A (Anionic) 644/665 D307
F70101FR-N Fluorescent DiR Control Liposomes for Clophosome® (Neutral) 750/780 D12731
F70101FR-A Fluorescent DiR Control Liposomes for Clophosome®-A (Anionic) 750/780 D12731

 

IMPORTANT NOTES FOR USING CLOPHOSOMES

CLEAN with alcohol and DO NOT reuse the needles

It is very important to follow this instruction, particularly for long-term macrophage depletion (more than a week). Animals become sensitive to infection when macrophages are depleted and their immune system is compromised. Animal sickness and even death may result if they are handled improperly. It is extremely important to conduct the injection in a clean environment. Withdraw the liposomes through the rubber stopper (clean with alcohol first) with a new sterile needle. Always clean the injection site with alcohol and use a new and sterile needle for each injection. Keep the animal cages clean.  Open the vials in a biological safety cabinet (BSC hood) and DO NOT contaminate the Clophosomes.

A good practice is to include a few extra animals for long-term experiments, as occasional animal death may occur. Test with a small group of animals first if you are a new user or using a new administration regimen. Treated properly these animals (mice) could survive for over a month even with twice-a-week injection of our clodronate liposomes.

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  • Clophosome(TM)  (2 mL and 10mL vials)
    $199.00 Clophosome® - Clodronate Liposomes (Neutral)
    Clophosome®- Clodronate Liposomes (Neutral) Clophosome®, neutral clodronate liposomes, offers highly efficient in vivo macrophage depletion. Clodronate molecules are encapsulated in small MLV liposomes for...

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    $359.00 Combo: Clophosome®, Fluorescent & Plain Control Liposomes (Neutral)
    Combo: Clophosome® and the Fluorescent and Control Liposomes Product code: F70101C-NC  This kit consists of the following items 1 vial (2 or 10mL) of Clophosome® - clodronate liposomes (F70101C-N) 1...

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    $169.00 Fluorescent DiO Control Liposomes for Clophosome (Neutral)
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