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Clophosome® - Clodronate Liposomes

 New product:  Liposomes for Loading Hydrophobic Drugs 

New product:  Alendrosome™- alendronate liposomes   

 New products: Lyophilized Clophosome® (1 year shelf-life)

 

FormuMax proudly offers two types of clodronate liposomes. Clophosome® with the clodronate molecules encapsulated in neutral liposomes is capable of achieving macrophage depletion of 80-90% in spleen after a single intravenous or intraperitoneal administration. Clophosome®-A composed of anionic lipids further improve the efficacy in macrophage depletion to above 90% in spleen after a single intravenous injection. Clodronate molecules are encapsulated in small MLV liposomes for superior activity, physical and chemical stability, and convenience of use and handling. 

Both types of Clophsome® are offered in the standard suspension form fo rthe convenience of use, the high potency form fo rdosing of high cotent with limited small volume and the lyophilized forms for the long shelf-life.

For your convenience, the products are provided in various combo kits and vial sizes (2mL and 10mL). Evaluation samples are also available upon request. See below for results and product details.

We have recently added two new forms of Clophosome® products. The first being the high potency neutral Clophosome® (20mg/mL) so that high amount of Clophosome® could be dosed when the dosing volume is small, such as intratracheal, intranasal,  Intracerebroventricular (ICV) or intratumor injections. 

We have also introduced lyophilized Clophosome® (both neutral and anionic forms) which give exceptional shelf-life of one year. The Clophosome® can be easily reconstituted to regenerate Clophosome® comparable to the original liquid Clophosome®. 

 

clophosome-flow-cyto-i.v..jpg                         

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.v. injection of liposomes (results used with permission)

 

clophosome-flow-cyto-i.p..jpg

Flow cytometry results demonstration depletion of F4/80-hi CD11b-lo/int macrophages of the mouse spleen 24 hr after i.p. injection of liposomes (results used with permission)

 (Note: the above results are illustrations only, your results may vary depending on individual applications, types of animals and administration regimens and many other factors) 

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  • Alenphosome™ - Alendronate Liposomes (Neutral) from FormuMax
    $599.00 Alendrosome™ - Alendronate Liposomes (Neutral)
    Alendrosome™ - Alendronate Liposomes (Neutral) We are looking for researchers to test our Alendrosome™ products, please contact us if you are interested Specifications Active: alendronate sodium...

  • Clophosome(TM)  (2 mL and 10mL vials)
    $199.00 Clophosome® - Clodronate Liposomes (Neutral)
    Clophosome®- Clodronate Liposomes (Neutral) Clophosome®, neutral clodronate liposomes, offers highly efficient in vivo macrophage depletion. Clodronate molecules are encapsulated in small MLV liposomes for...

  • Clophosome(TM)  (2 mL and 10mL vials)
    $399.00 Clophosome® - High Potency Clodronate Liposomes (Neutral, 20mg/mL)
    High Potency Clophosome®- Clodronate Liposomes (Neutral, 1.0 mL, 20 mg/mL) High potency Clophosome® is created to satisfy the demand for small volume dosing of concentrated clodronate liposomes through routes that...

  • Clophosome-A™- Clodronate Liposomes (anionic) available from FormuMax
    $299.00 Clophosome®-A - Clodronate Liposomes (Anionic)
    Clophosome®-A- Clodronate Liposomes (Anionic) Clophosome®-A, negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes...

  • Clophosome®-A, Fluorescent & Plain Control Liposomes
    $519.00 Clophosome®-A, Fluorescent & Plain Control Liposomes
    Combo: Clophosome® - A, the Fluorescent liposomes and the Control Liposomes Product code: F70101C-AF  This kit consists of the following items 1 vial (2 or 10mL) of Clophosome® - clodronate...

  • Combo Kit:  Clophosome®, Clophosome®- A And Control Liposomes
    $599.00 Combo Kit: Clophosome®, Clophosome®- A And Control Liposomes
    Combo:  Clophosome® and Clophosome®-A And Control Liposomes This all-in-one set is an excellent choice if you want to evaluate and compare the two clodronate liposome products. Included in this kit are one...

  • Clophosome™- Clodronate Liposomes (Neutral) and its control liposomes from FormuMax
    $239.00 Combo: Clophosome® and Control Liposomes
    Clophosome® and Control Liposomes Combo Included in this convenience combo kit are 1 vial of the neutral clodronate liposomes and 1 vial of control liposomes. You save 20%.   Product code:...

  • Combo: Clophosome®, Fluorescent & Plain Control Liposomes (Neutral)
    $359.00 Combo: Clophosome®, Fluorescent & Plain Control Liposomes (Neutral)
    Combo: Clophosome® and the Fluorescent and Control Liposomes Product code: F70101C-NC  This kit consists of the following items 1 vial (2 or 10mL) of Clophosome® - clodronate liposomes (F70101C-N) 1...

  • Combo: Clophosome®-A and Control Liposomes (anionic)
    $349.00 Combo: Clophosome®-A and Control Liposomes (anionic)
    Combo: Clophosome®-A and Control Liposomes  Included in this convenience combo kit are 1 vial of the anionic clodronate liposomes and 1 vial of the anionic control liposomes. Your save is more than 20%...

  • Control liposomes for Alendrosome™ - (Neutral)
    $199.00 Control liposomes for Alendrosome™ - (Neutral)
    Control Plain Liposomes for Alendrosome™ (Neutral) Specifications Active: none Volume: 10.0 mL Lipid composition: phosphatidylcholine and cholesterol Internal/External solution: phosphate...

  • Control liposomes for Clophosome (right)
    $149.00 Control Liposomes for High Potency Clophosome® (Neutral, 1.0mL)
    Empty Control Liposomes for high potency Clophosome® (Neutral, 1.0mL) This product of empty liposomes are made to match the physical and chemical attributes of the high potency neutral Clophosome® without the...

  • Control liposomes for Clophosome (right)
    $219.00 Control Liposomes for High Potency Clophosome® - A (Anionic)
    Empty Control Liposomes for high potency Clophosome® (Anionic, 1.0 mL) This product of empty liposomes are made to match the physical and chemical attributes of the high potency anionic Clophosome® without the...

  • Control liposomes for Clophosome (right)
    $259.00 Control Liposomes for Lyophilized Clophosome® -A (Anionic, 5mL)
    Lyophilized Empty Control Liposomes for Clophosome® - A (anionic, 5.0mL) This product of empty liposomes are made to match the physical and chemical attributes of the lyophilized Clophosome® without the active...

  • Control liposomes for Clophosome (right)
    $169.00 Control Liposomes for Lyophilized Clophosome® (Neutral, 5mL)
    Lyophilized Empty Control Liposomes for Clophosome® (Neutral, 5.0mL) This product of empty liposomes are made to match the physical and chemical attributes of the lyophilized Clophosome® without the active...

  • DiI Fluorescent Control Liposomes (Neutral)
    $149.00 DiI Fluorescent Control Liposomes (Neutral)
    DiI-Labeled Fluorescent Control Liposomes for Clophosome® (Neutral) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and chemical...

  • DiI Fluorescent Control Liposomes for Clophosome®-A (Anionic)
    $199.00 DiI Fluorescent Control Liposomes for Clophosome®-A (Anionic)
    DiI-Labeled Fluorescent Control Liposomes for Clophosome®-A (Anionic) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and...


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