Doxoves® - PEGylated Liposomal Doxorubicin HCl
Doxorubicin HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) with ammonium gradient by the active loading approach. It is comparable to the commercial product DOXIL®. The liposomes are prepared to very high quality with consistent lot-lot characteristics. Narrow particle size distribution and high drug encapsulation efficiency. Note the high drug concentration (4mg/mL compared to 2 mg/mL for DOXIL®) allows the researchers to perform experiments at higher concentration/doses.
For preclinical research in animal models only. Not for veterinary or human use
Orders are only accepted from verified institutional, academic, or corporate laboratory addresses. We do not ship to individuals or residential addresses
Specifications
Product code: F30204B-D
Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol)
Lipid concentration: 40.0 mM
Doxorubicin HCl: 4.0 mg/mL
Encapsulation efficiency: > 95% (typically 98%)
Loading battery: 250 mM ammonium sulfate
Mean particle size: 85 nm (80 - 90 nm)
External solution: 10% sucrose, 10 mM histidine, pH 6.5
Shelf-life: 6 months, storage: 2-8 degree C
HSPC: hydrogenated phosphatidylcholine (Soy)
CHOL: cholesterol
mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
