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Analytical and Characterization

Formulation Physical Characterization

  • Particle size (Brookhaven ZetaPALS)
  • Zeta Potential and Mobility (Brookhaven ZetaPALS)
  • Particle size distribution (Cryo-TEM)
  • Drug encapsulation efficiency
  • Particle shape, lamellarity and particle Sub-structure (cryo-TEM, FF-EM)
  • Lipid phase transition, polymer glass transition, melting point (Perkin Elmer DSC)
  • Lyophylization/Freeze trying (Virtis Genesis)

Analytical Sciences
  • HPLC method development (Agilent 1100 HPLC, Waters 2695)
  • HPLC measurement of drug potency and degradents
  • Lipid assay
  • Formulation stability (chemical and physical)
  • In vitro drug release assay
  • pH
  • Osmolarity
  • Refractive Index
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