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Analytical and Characterization

Formulation Physical Characterization
  • Particle size and distribution (Brookhaven ZetaPALS)
  • Zeta Potential and Mobility (Brookhaven ZetaPALS)
  • Drug encapsulation efficiency
  • Lipid/liposome phase transition, enthalpy (MicoCal VP-DSC)
  • Polymer glass transition, melting point (Perkin Elmer DSC 7)
  • Lyophylization/Freeze trying (Virtis Genesis)

Analytical Sciences
  • HPLC method development (Agilent 1100 HPLC, Waters 2695)
  • HPLC measurement of drug potency and degradents
  • Lipid assay
  • Formulation stability (chemical and physical)
  • Lipid/liposome phase transition, enthalpy (MicoCal VP-DSC)
  • Polymer glass transition, melting point (Perkin Elmer DSC 7)
  • In vitro drug release assay
  • pH
  • Osmolarity (Wescor Vapro Osmometer 5520 and OSMETTE XL™ 5007 )
  • Refractive Index
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