We provide contract services of drug delivery formulation developments to pharmaceutical/biotech industries. We specialize in a range of formulation and drug delivery technologies for injectables, from conventional liposomes, Stealth (PEGylated) liposomes for drug encapsulation and slow release to solubility enhancing systems such as microemulsions and liposomes. We have strong and broad expertise with near thirty years of experience in the drug delivery field and lipid biophysics. Our services include formulation development, characterization, analytical and nonclinical services.

Formulation Development

  Ø  All types of liposomes and other lipid-based drug delivery systems

  Ø  Specialized in formulation of difficult compounds

  Ø  Formulation of small molecules, peptides/proteins, nucleic acids

  Ø  Solubility enhancement using liposomes and lipid-based systems

  Ø  Controlled/slow drug release systems

  Ø  Pre-formulation, formulation feasibility and prototype development

  Ø  Scale-up, composition/process optimization (Design-of-Experiments)

  Ø  Extrusion, homogenization, microfluidization, sonication and others 

Formulation Characterization

  Ø  Particle size (Brookhaven 90Plus part of ZetaPALS) (90plus link)

  Ø  Zeta Potential and Mobility (Brookhaven ZetaPALS) (Link)

  Ø  Particle size distribution (Brookhaven ZetaPALS, Cryo-TEM)

  Ø  Drug encapsulation efficiency (various approaches)

  Ø Microscope examinations (uniformity, drug crystals by microscope, centrigugation)

  Ø  Particle shape, lamellarity and particle Sub-structure (cryo-TEM, FF-EM)

  Ø  Phase transition, enthlpy of lipid vesicles and liposomes, protein denaturation tmperatures (Microcal VP-DSC) 

  Ø Polymer glass transition, melting point (Perkin Elmer DSC 7)

  Ø  Lyophylization/Freeze trying (liposomes, peptide/proeins, Virtis Genesis 35EL with stoppering)

Analytical Sciences

  Ø  HPLC method development (Agilent 1100 HPLC, Waters 2695)

  Ø  HPLC measurement of drug potency and degradents

  Ø  Lipid concentration assay

  Ø  Formulation stability (chemical and physical)

  Ø  In vitro drug release assay

  Ø  pH

  Ø  Osmolality (two different instruments)

  Ø  Refractive Index

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