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STEALTH Liposomal Irinotecan HCl (2.0mg/mL)

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3 day

Product Description

PEGylated Liposomal Irinotecan HCl

Irinotecan HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) with ammonium gradient by the active loading approach. The liposomes are produced by the extrusion method. The product is of high quality with narrow particle size distribution and high drug encapsualtion efficiency. 


Product For Research only and NOT for Human Use


Product code: F30204S-IT

Lipid composition:  HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol)

Lipid concentration:  20.0 mM

Iroinotecan HCl:  2.0 mg/mL

Encapsulation efficiency: > 95% (typically 98%)

Loading battery:  250 mM ammonium sulfate

Mean particle size:  100 nm (80-110 nm)

External solution:  10% sucrose, 20 Mm HEPES, pH 7.0

Shelf-life: 3 months, storage: 2-8 degree C


Irinotecan: Synonym: (S)​-​4,11-​diethyl-​3,4,12,14-​tetrahydro-​4-​hydroxy-​3,14-​dioxo-​1H-​pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, CPT-11, [1,4′-Bipiperidine]-1′-carboxylic acid 

CAS Number 100286-90-6, Empirical Formula: C33H38N4O6 · HCl, Sigma Cat# I1406

HSPC: hydrogenated phosphatidylcholine (Soy)

CHOL: cholesterol

mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

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