High Potency Clophosome®

The high potency neutral Clophosome® are provided at 20mg/mL so that high content of clodronate could be dosed when the dosing volume is small, such as intratracheal, intranasal,  Intracerebroventricular (ICV) or intratumor injections. 

Note: dosing volume for these high potency Clophsome® products have not been fully assessed, so test before conducting the final study.

High Potency Clophosome® 

   Product Code   Description          Price (1 mL)
   F70101C-NH (New) 
 Clophosome® - high potency clodronate liposomes (neutral)
               $399
   F70101-NH (New)
 Control empty liposomes for Clophosome®, high potency (neutral)
               $149
   F70101C-AH (New)
 Clophosome® -A- high potency clodronate liposomes (anionic)
               $499
   F70101-AH (new)
 Control empty liposomes for Clophosome® - A, high potency (anionic)
               $219

 

IMPORTANT NOTES FOR USING CLOPHOSOMES

CLEAN with alcohol and DO NOT reuse the needles

It is very important to follow the instruction, particularly for long-term macrophage depletion (more than a week). Animals become sensitive to infection when macrophages are depleted and their immune system is compromised. Animal sickness and even death may result if they are handled improperly. It is extremely important to conduct the injection in a clean environment. Withdraw the liposomes through the rubber stopper (clean with alcohol first) with a new sterile needle. Always clean the injection site with alcohol and use a new and sterile needle for each injection. Keep the animal cages clean.  Open the vials in a biological safety cabinet (BSC hood) and DO NOT contaminate the Clophosomes.

A good practice is to include a few extra animals for long-term experiments, as occasional animal death may occur. Test with a small group of animals first if you are a new user or using a new administration regimen. Treated properly these animals (mice) could survive for over a month even with twice-a-week injection of our clodronate liposomes.