We specialize in a range of formulation and drug delivery technologies from solubility enhancement using various solubility enhancing systems to more sophisticated nano-enabled systems like PEGylated liposomes (STEALTH liposomes), PEGylated lipospheres and polymer-based nanoparticles for controlled/sustained delivery of various type of compounds. We have strong expertise and over twenty years of experience in designing and developing delivery systems with respect to the drug carrier systems, and the drug loading and drug retention technologies. We provide formulation and analytical services to a wide range of industries from pharmaceutical and biotech to cosmetic and nutraceutical.

Formulation Development

• Liposomes and other lipid-based drug delivery systems
• Specialized in difficult-to-formulate compounds
• Extrusion, homogenization/microfluidization, sonication and others
• Controlled/slow drug release system
• Solubility enhancement
• Nanocrystal down-sizing and polymer coating
• Pre-formulation, formulation feasibility, and prototype development
• Formulation characterization, stability, in vitro/in vivo studies
• Scale-up and optimization
• Optimization of formulation process and carrier matrix
• Formulation development for pharmaceuticals, cosmetics, nutraceutical and etc

 Evaluation of active drug loading into liposomes

• Qa-Test (2 weeks turn-around) (inquire)
  • Test for loadbility of compounds to STEALTH liposomes
  • Return of sufficient amount of formulation to customer 

 Solubility enhancement of insoluble compounds

• Qs-Test (2 weeks turn-around (inquire)
  • Screening using a set of solubilization matrixes
  • Monitor stability for one week
  • Return of sufficient amount of the best formulation to customer

Analytical Science, Characterization and Nonclinical

• Formulation physical characterization
  • Particle size and distribution (ZetaPALS, NICOMP370, Coulter particle sizer, Cryo-EM)
    
  • Zeta Potential (ZetaPALS)
    
  • API encapsulation efficiency
  • Electron-microscopy (cryo-EM, FF-EM)
  • pH
  • Osmolility
  • Refractive Index
    
• HPLC method development
• Formulation stability
• In vitro drug release assay
• Nonclinical studies (PK, anti-tumor efficacy)